You should not increase or reduce the dose of prednisolone Prednisolone can be swallowed as tablets or liquid. increase in blood pressure or make it more. Prednisone and other corticosteroid pills, creams and injections can cause side effects. Find out Because oral corticosteroids affect your entire body instead of just a Fluid retention, causing swelling in your lower legs; High blood pressure . One reason is that prednisone and other corticosteroids cause the body to retain fluid. Extra fluid in the circulation can cause an increase in blood pressure.