Whether or not you're a little skeptical about giving your doggie prednisone. Prednisone is activated by the patient's liver to prednisolone. In general, these medications are considered interchangeable in dogs but cats seem to have less . The corticosteroids most commonly used for dogs include either prednisone or prednisolone although others are also available. Corticosteroids. Infertility in Mares. Cortisol is the naturally occurring corticosteroid hormone. Estrus Control in Performance Horses. Water, Horses Drinking Too Much? Had bad dry mouth and his hip muscle was completely gone.