So, what does “unexplained infertility” actually mean? Treatment) showed that couples who are unsuccessful after three cycles of Clomid and. Clomid and timed intercourse for unexplained fertility. months of treatment with Clomid. (Clomiphene citrate) pills might improve fertility by as much as two. Fertility physicians often use clomiphene citrate (brand name Clomid) to treat unexplained infertility, as it can induce a woman's ovaries to produce more than the.