I have been on Clomid for the last three months and I have gained 10 pounds. I have been the same weight for years and years. Has anyone. OBJECTIVE: Clomid has been approved in women with PCOS/ovulation induction. tients reported weight gain, two had elevated liver function tests and one. Weight Gain On Clomid??? Have taken 4 rounds of Clomid to date and I'm feeling absolutely awful! My body is totally confused. Gaining weight like crazy and. It does this by blocking estrogen receptors. I gained weight on and although I'm sure my diet didn't help part of it was the clomid I'm sure of it. That makes me feel better knowing I'm not the only one. Hair shows normal male-pattern hair distribution groomed. Table 4 Clinical characteristics and metabolic parameters before and after each treatment period in all subjects and according to their metabolic state IGT or T2DM. TXT Click here for additional data file. Baseline characteristics of the subgroups with IGT or T2DM were compared by means of the one-way analysis of variance ANOVA while, in order to analyze the endpoint data according to the study design, the 4-way repeated measure ANOVA was applied by considering two intra-subject factors and two inter-subject factors. I'm usually pretty good with any medication but with Clomid I've had every side effect under the sun! Even oxycodone prednisone and the existing literature presents some contradictory data on the effect of MET on testis functions [ 3940 ], our findings are in accordance with studies carried out in diabetic rats in which MET was shown to inhibit the diabetes-induced damages in testicular tissue, increasing plasma levels of T, LH and FSH as well as reducing Sertoli cell [ 41 ] and germ cell apoptosis [ 42 ]. Thank goodness I'm not the only one I have gained lbs since starting clomid and considering its not working it just frustrates me.