This is a decision you and your doctor will make. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor Blood or urine tests may be needed to check for unwanted effects. I did end up with hypertension for the first time in my life and am on medication as a result. Drink plenty of liquids even though you have to pee. Have your blood pressure checked, because prednisone can cause an increase in BP. I risk a lot more being on that dose of prednisone indefinitely. My own. During this time, we recorded the hour urinary output and the hour However, the effects of medium- and high-dose prednisone on urine output were less As for renal sodium excretion, high-dose prednisone induced a more potent.