Prednisone is a corticosteroid (cortisone-like medicine or steroid). This is a decision you and your doctor will make. . If you use this medicine for a long time , do not suddenly stop using it without checking first with your doctor. fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination. Taking prednisolone can make you more likely to get infections. not heal - these can be signs of an infection; sleepy or confused, feeling very thirsty or hungry. 4 Answers - Posted in: prednisone - Answer: Hello KathyBass. Yes it can make you thirsty. Regards pledge. Call your doctor for medical advice about side effects. The serving how viagra affect women tells what a single portion of a food is. Keep from freezing. Once you stop taking prednisolone, any issues around increased appetite or water retention should return to normal. If you have diabetesyou may need to check your blood glucose more often. Are there other steroids? If you have a "live" vaccine, like the shingles vaccine, while you are taking prednisolone your immune system might not be able to handle it. People with diabetes may find their blood glucose control is not as good as it usually is while they are taking prednisone. There is a fine line between too predhisone or too little prednisone. If you use this medicine for a long time, do not suddenly stop using it without checking first with your doctor.