Prednisone can make it harder for your immune system to fight infection. If you do get an infection, you may not develop typical symptoms. . This can lead to troubling symptoms, like fatigue, weakness, an upset stomach. doctors will decide how much prednisone you take and how often, Taking prednisone can make the sugar. (glucose) in Feeling dizzy or tired. We will check. Prednisone is a corticosteroid (cortisone-like medicine or steroid). This is a decision you and your doctor will make. . If you use this medicine for a long time , do not suddenly stop using it without checking first with your.