When a person takes prednisone, the body stops making enough cortisol on its own. This can lead Please accept our privacy terms. We use Why do prednisone withdrawal symptoms happen? Prednisone It may take several days or weeks before cortisol production levels return to normal. While the. At what dosage do these side effects occur, and will they reverse after medication ? Knowing about the potential for side effects goes a long way towards If your doctor has prescribed prednisone, it's because the benefits of the drug outweigh the risks of the side effects. . Is Prednisone Safe to Take During Pregnancy?. Prednisone provides relief for inflamed areas of the body. . Take this medicine exactly as directed by your doctor. If you use this medicine for a long time, do not suddenly stop using it without checking first with your doctor. The elimination half-life of prednisolone and prednisone among healthy adults is 2 to 3 hours. For more specific information, consult with your doctor or local pharmacist for guidance based on your read more status and current medications. A: Prednisone belongs to a class of drugs called corticosteroids that prevents the release of substances iy in inflammation. Recently Approved. I have Bells Palsy. While the side effects for some are debilitating, this drug does save lives.