There is a fine line between too much or too little prednisone. If you take prednisone on a daily basis, for a long period of time, it can cause. “Others should be taken at night, because they may cause drowsiness. “I tell people to take prednisone first thing in the morning, with something in their stomach Tremia Appling, 41, of Oklahoma City, OK, says, “You really need to be good. Prednisone causes acute insomnia, which will cost you of your good night's sleep , you of your most prized procession 'sleep', but that's if you take it for granted. like melatonin and chamomile, they are just safe over-the-counter treatment.