Methylprednisolone is used to treat conditions such as arthritis, blood disorders, severe allergic reactions, certain cancers, eye conditions. Methylprednisolone (Medrol, Depo-Medrol, Solu-Medrol) is a drug used to achieve prompt suppression of inflammation. Article includes descriptions, uses, drug. Methylprednisolone is used to treat conditions such as allergies, arthritis, lupus and ulcerative colitis. Learn about side effects, interactions and.