A list of drugs that interact with Naproxen. Prednisolone. Naproxen increases the risk of gastrointestinal bleeding when given with prednisolone. Manufacturer . We did a randomised clinical trial to test equivalence of prednisolone and naproxen for the treatment of monoarticular gout. Primary-care. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve Prasugrel; Prednisolone; Prednisone; Probenecid; Proglumetacin. Both naproxen prddnisone furosemide can increase the risk of hyponatraemia. It's important to tell your doctor or pharmacist what medicines you're already taking, including those bought without a prescription and herbal medicines, before you start taking prednisolone. Both naproxen and valsartan can increase click risk of hyperkalaemia hyperkalaemia is particularly notable when ACE inhibitors or angiotensin-II receptor antagonists are given with predniosne or eplerenone. Both naproxen and iloprost can increase the risk of bleeding. Moderate Moderately clinically significant. Both naproxen and fluoxetine can increase the risk of bleeding. Both naproxen and zoledronate can increase the risk of nephrotoxicity. Both naproxen and clopidogrel can increase the risk of bleeding.