Prednisone oral tablet is a prescription drug used to treat inflammation from conditions such as multiple sclerosis and rheumatoid arthritis Learn about side effects, warnings, dosage, and more. Older adults may process drugs more slowly. Prednisone is a corticosteroid (cortisone-like medicine or steroid). It works on . Adults—At first, 5 to 60 milligrams (mg) per day. Your doctor. Medscape - Anti-inflammatory-specific dosing for Prednisone Intensol ( prednisone), frequency-based adverse effects, comprehensive interactions.