Treatment of Severe Poison Ivy: A Randomized, Controlled Trial of Long Versus Short Course Oral Prednisone. Article (PDF Available) in Journal of Clinical. What are the proven and unproven treatment options for this common problem? Standard prescription therapy for poison ivy is administration of prednisone in. A nonblinded randomized controlled trial evaluated 49 patients, 14 years old or above, with severe contact dermatitis from poison ivy. Severe contact.