Taking medications during pregnancy is a reality for many women with IBD. Learn the risks of taking prednisone during pregnancy. This sheet talks about exposure to oral prednisone or prednisolone in a pregnancy or while breastfeeding. This information should not take the. Prednisone is a glucocorticoid medication mostly used to suppress the immune system and MedlinePlus · a · Pregnancy category. AU: A; US: C (Risk not ruled out). Routes of administration It is generally considered safe in pregnancy and low doses appear to be safe when breastfeeding. After prolonged use.