Prednisone is a corticosteroid or “steroid” for short. Take it after meals or with food or milk—prednisone loves to cause upset stomach and. If your stomach still feels sore after taking prednisone with food, try taking an antacid. If the discomfort persists or gets worse, talk to your doctor. you are taking prednisolone or prednisone. immediately after food. . Taking prednisolone with food can reduce this. • Ulcers: If taken with nonsteroidal anti-.