High dose >30 mg, but ≤ mg prednisone equivalent a day For genomic effects the degree of cytosolic receptor saturation is considered as a direct. 1) How much prednisone is ok to take daily if I needed to for years to come? The effects are dose related– higher the dose, the worse the side effects. A dose of 5 mg daily use to be considered acceptable, but current. If you take prednisolone for more than 3 weeks, or you're on a high dose, you'll get a blue steroid card. Show this card to your doctor or dentist before any.